Historically, the influenza A virus has been responsible for millions of deaths worldwide each year. The persistence of seasonal H1N1 and H3N2 strains costs between 3,000 and 49,000 lives annually in the United States alone. Influenza pandemics, or global circulations of highly transmissible and pathogenic viral strains, have occurred four times in the past century. The 1918 H1N1 Spanish Flu was particularly devastating, killing as many as 100 million people worldwide. We have built a full atomic model of the influenza envelope, comprised of 210 million atoms. In order to gain unprecedented insights into the mechanisms of influenza virulence that will accelerate anti-viral therapeutics development, we are running molecular dynamics (MD) simulations of this system on the Stampede Xeon Phi co-processors. To read further, please visit https://www.tacc.utexas.edu/-/real-science-using-stampede-s-xeon-phi.